Primary Toxic and Carcinogenic Components of Cigarette Smoke

Cigarette smoke contains over 4,700 chemical compounds of which about 60 are carcinogenic. The following tables, sourced from US Surgeon General Reports on the Health Consequences of smoking summarise the toxic components of cigarettes.
Carbon Monoxide                            
Nitrogen Oxides
Ammonia
Acrolein
Acetaldehyde
Arsenic
Polonium-210
Hydrazine
Vinyl Chloride
Urethane
2-Nitropropane
Quinoline
Nickel
Cadmium
Nitrosodimethylamine
Nitrosoethymethylamine
Nitrosodiethylamine
Nitrosodi-n-propylamine
Nitrosodi-n-butylamine
Nitrosopyrrolidine
Nitrosopiperidine
Nitrosomorpholine
N'-Nitrosonornicotine
4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
N'-Nitrosoanabasine
N'-Nitrosoanatabine
Aromatic Amines
Aromatic Nitrohydrocarbons
Toxin
Toxin
Toxin
Ciliotoxic
Ciliotoxic
Carcinogenic
Carcinogenic
Carcinogenic
Carcinogenic
Carcinogenic
Carcinogenic
Carcinogenic
Carcinogenic
Carcinogenic
Carcinogenic
Carcinogenic
Carcinogenic
Carcinogenic
Carcinogenic
Carcinogenic
Carcinogenic
Carcinogenic
Carcinogenic
Carcinogenic
Carcinogenic
Carcinogenic
Carcinogenic
Carcinogenic




Carcinogenic = Cancer
Benzo[a]pyrene
Dibenz[a,h]anthracene
Benzo[b]fluoranthene
Benzo[j]fluoranthene
Dibenzo[a,h]pyrene
Dibenzo[a,i]pyrene
Dibenz[a,j]acridine
Indeno[1,2,3-cd]pyrene
Benzo[c]phenanthrene
Benz[a]anthracene
Benzo[e]pyrene
Chrysene
Methylchrysene
Mehtylfluoranthene
Dibenz[a,c]anthracene
Dibenz[a,h]acridine
Dibenzo[c,g]carbazole
Mehtylnaphtalenes
1-Methylindoles
Dichlorostilbene
Catechol
3-Methycatechol
4-Methycatechol
4-Ethycatechol
4-n-Propylcatechol
Hydrogen Cyanide
Formaldehyde
Carcinogenic / Co-carcinogenic
Carcinogenic / Co-carcinogenic
Carcinogenic / Co-carcinogenic
Carcinogenic / Co-carcinogenic
Carcinogenic / Co-carcinogenic
Carcinogenic / Co-carcinogenic
Carcinogenic / Co-carcinogenic
Carcinogenic / Co-carcinogenic
Carcinogenic / Co-carcinogenic
Carcinogenic / Co-carcinogenic
Carcinogenic / Co-carcinogenic
Carcinogenic / Co-carcinogenic
Carcinogenic / Co-carcinogenic
Carcinogenic / Co-carcinogenic
Carcinogenic / Co-carcinogenic
Carcinogenic / Co-carcinogenic
Carcinogenic / Co-carcinogenic
Co-carcinogenic
Co-carcinogenic
Co-carcinogenic
Co-carcinogenic
Co-carcinogenic
Co-carcinogenic
Co-carcinogenic
Co-carcinogenic
Toxin / Ciliotoxic
Ciliotoxic / Carcinogenic

Cigarette smoking is responsible for more than 85% of lung cancers and is also associated with cancers of the mouth, pharynx, larynx, oesophagus, stomach, pancreas, uterine cervix, kidney, urether, bladder and colon. Cigarette smoking has also been linked to Leukaemia. Apart from the carcinogenic aspects of cigarette smoking, links to increased risks of cardiovascular diseases (including stroke), sudden death, cardiac arrest, peripheral vascular disease and aortic aneurysm have also been established. Many components of Cigarette smoke have also been characterised as Ciliotoxic materials that irritate the lining of the respiratory system resulting in increased bronchial mucus secretion and chronic decreases in pulmonary and mucociliary function.

The Toxicology of Cigarette Smoke and Environmental Tobacco Smoke by Stephen Mulcahy, 9224076

Report Assignment - Biochemical Toxicology BC4927


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